Activity of the alpha-1 antitrypsin deficiency registry in Belgium.

Prevalence of Alpha-1 Antitrypsin (A1AT) Deficiency among Patients with COPD in Kerman, Iran

Background: One of the genetic risk factors for chronic obstructive pulmonary disease (COPD) is deficiency of Alpha-1 Antitrypsin (A1AT). There is no exact statistics about the prevalence of this disease in different regions of Iran. The present study aimed to determine the prevalence of alpha-1 antitrypsin (A1AT) deficiency in COPD patients in Kerman, Iran. Metho...

Alpha- 1 Antitrypsin Deficiency in Children: Pulmonary Involvement

Introduction: α1-antitrypsin deficiency (α1-ATD) is one of the most common genetic disorders in white race, a usual cause of liver disease in children, and hepatopulmonary involvement in children and adult. The aim of this case description is presenting a child with early lung disease without liver parenchymal disorder. Case presentation: We describe a 13 year old boy because of exertional dysp...

[Profiles of cases included in the Spanish registry of patients with alpha-1 antitrypsin deficiency].

Comparison The Activity Rate of Alpha-1 Antitrypsin in Obese with normal weight People

  Background & Objective: Obesity is one of the most important global health priorities as far as it increases illnesses and disorders the life quality. Alpha-1-Antitrypsin (AAT) is the most abundant serum protease inhibitor and prevents tissue degradation through proteases. Hence, its defect or deficiency significantly increases the risk of various diseases. AAT may be involved in the developm...

Determination of Alpha 1-Antitrypsin Phenotypes and Genotypes in Iranian Patients

Alpha 1-antitrypsin (AAT) or alpha 1-protease inhibitor (PI) is the principal inhibitor of proteolytic enzyme in serum. Its phenotypic variability has been reported to be associated with liver, lung diseases and rheumatoid arthritis in humans. There is much documentation about high risk phenotypes of PI in some regions of the world, however, there are no reliable reports on these phenotypes and...